pentobarbital will reduce the extent or influence of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.pentobarbital will reduce the level or impact of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Loss of, or diminished reaction to tofacitinib may hap